The new trend in social networking these days is to use TweetDeck as one's means of communication. This is done by setting up a profile for your business on the Twitter service and then building a TweetDeck, a central location for all of your social networking accounts. With TweetDeck, it is possible to organize all your accounts in the way that you want, and you can customize it as needed. This will save you a lot of time, especially if you run a small business.
TweetDeck isn't available for the iPhone yet, but there are a lot of options with similar functionality already out there. The ideal solution is always going to be using a third-party solution, as this is what most individuals are used to having done. The best Android option is definitely Hootsuite, which isn't free but is reasonably priced and easily downloaded.
Hootsuite has a very nice interface, and it allows users to customize how their columns look, as well as how they act. This is a great way to go if you're looking for a functional yet aesthetic Twitter interface, since it manages to combine the best parts of TweetDeck, while providing a bit more convenience for the regular Twitter user. In addition to this, Hootsuite also provides a useful feature that allows you to see the last few updates on your own personal Twitter stream, so you know when something important happens on the right column that you may want to follow up on.